By Brian McTaggart MLB.com
HOUSTON -- Chris Colabello hit a grand slam with two outs in the ninth inning off reliever Chia-Jen Lo on Monday afternoon to lead the Twins to a 10-6, come-from-behind win over the Astros in the series opener at Minute Maid Park.
Lo, the Astros' fifth pitcher of the game, walked a pair of batters after two outs to load the bases for Colabello, who blasted the first pitch into the Astros' bullpen in right-center field for his second homer of the game.
The Astros lost the game after leading, 5-1, after two innings.
Astros All-Star catcher Jason Castro left the game in the second inning with a sprained right knee after going 2-for-2 with two RBIs. That's the same knee in which Castro had his ACL surgically repaired two years ago, costing him in the 2011 season.
The Astros staked Clemens to a 5-1 lead through two innings, scoring early and often against Twins starter Andrew Albers.
Nine of the Astros' first 12 batters in the game reached base on a hit, with Castro, Chris Carter and Trevor Crowe coming through with RBI singles for a 3-0 lead in the first. Castro and Carter came through with RBI hits again in the second to make it 5-1.
Castro was removed from the game following his second-inning single, with Cody Clark taking his place behind the plate.
The Twins slowly chipped away against Clemens, getting a two-out RBI double by Darin Mastroianni in the third. Colabello homered in the fourth to trim the lead to 6-3, and Clemens gave up an unearned run on a single by Pedro Florimon later in the inning.
Brian Dozier led off the fifth inning with a homer into the Crawford Boxes off Astros reliever Lucas Harrell that cut the Astros' lead to 6-5.
Clemens, making his second Major League start, worked 3 2/3 innings and allowed four runs (three earned) and seven hits.
Josh Fields threw two scoreless innings in relief and was pulled after walking Trevor Plouffe to start the eighth. That proved to be costly because pinch-runner Doug Bernier scored the tying run on a two-out single by Florimon off Kevin Chapman.